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KMID : 0378019700130090077
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New Medical Journal
1970 Volume.13 No. 9 p.77 ~ p.96
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Experimental Study on Transplantation of Walker Carcinosarcoma 256
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Abstract
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Bone tumors in Orthopedic Surgery, have been studied recently by many authors.
One of the big problems is that even though there are many methods of treatment, the result are not satisfactory and a good prognosis can not be expected without the use of specific anticancer drugs. Therefore, experimental transplantation of bone tumor is very important as a fundamental study for further investigation of cancer problems.
Many experimental transplantation have been done in the field of Orthopedic Surgery subcutaneously, intramuscularly and intramedullary, but we can not find any experimental reports about sJbperiosteal and parosteal trasplantation of tumor cells. We transplanted the Walker Carcinosarcoma 256 intramedullary (Group I ), subperiosteally (Group II) and parosteally (Group III) into the distal portion of the right femur of white rats.
The result are as follows:
1. Transplantation rate is
a. within 2 hours b. between 3-4 hours
Group I : 87.5% Group I : 44.4
Group II : 78.6% Group l : 80.0%
Group III : 93.6% Group Il : 80. 0%
2. Palpable tumor mass was initially found
Group I : 9-12 days
Group II : 6-9 days
Group III : 6-7 days
3. Body weight was increased in all experimental groups after 17-22 days compared with the control group which was due to increasing of tumor mass.
4. Anemia developed markedly in Group I after 12 days and Group II after 15 days but slightly in Group III. WBC count was markedly elevated in Group I after 12 days and Group II after 21 days but developed later and lesser degree in Group III.
5. In X-ray studies, destructive bone changes and periosteal reaction was noted in Group I at 12 days and some periosteal reaction was noted in small numbers of Group II at 21 days but no bone change or periosteal reaction could be found in Group III.
6. All experimental transplanted tumors were confirmed histopathologically. Carcinomatous pattern was more predominant in Group I and II, and Sarcomatous pattern in Group III
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KEYWORD
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